Zhe Wang
Publications
Learning Multi-Relational Graph Representations for DNA Methylation-Based Biological Age Estimation
Aging clocks aim to estimate biological age, a measure of physiological state distinct from chronological age, from observable biomarkers, and are widely used for health assessment and disease analysis. DNA methylation is a particularly informative biomarker due to its stability and strong association with aging, and recent learning-based approaches have improved predictive performance. However, most existing methods treat CpG sites as independent features, overlooking the complex and heterogeneous biological relationships among them. We propose RelAge-GNN, a multi-relational graph neural network framework for DNA methylation-based age prediction. Our method constructs three complementary graphs capturing co-methylation patterns, genomic co-localization, and gene-level associations among CpG sites. Each graph is modeled by an independent GNN branch, and a learnable gating mechanism adaptively fuses the resulting representations. Experiments on large-scale datasets show that RelAge-GNN achieves competitive accuracy and stronger correlation with chronological age compared to state-of-the-art methods. Moreover, the model exhibits improved sensitivity in detecting age acceleration across diverse disease cohorts, highlighting its potential utility for disease characterization. Finally, through post hoc interpretability analyses, we quantify the contributions of different relational structures and CpG sites, providing biologically meaningful insights and suggesting potential directions for aging-related research. Our code is available at: https://anonymous.4open.science/r/RelAge-GNN-F1E3/.
Bridging Semantic Understanding and Popularity Bias with LLMs
Semantic understanding of popularity bias is a crucial yet underexplored challenge in recommender systems, where popular items are often favored at the expense of niche content. Most existing debiasing methods treat the semantic understanding of popularity bias as a matter of diversity enhancement or long-tail coverage, neglecting the deeper semantic layer that embodies the causal origins of the bias itself. Consequently, such shallow interpretations limit both their debiasing effectiveness and recommendation accuracy. In this paper, we propose FairLRM, a novel framework that bridges the gap in the semantic understanding of popularity bias with Recommendation via Large Language Model (RecLLM). FairLRM decomposes popularity bias into item-side and user-side components, using structured instruction-based prompts to enhance the model's comprehension of both global item distributions and individual user preferences. Unlike traditional methods that rely on surface-level features such as "diversity" or "debiasing", FairLRM improves the model's ability to semantically interpret and address the underlying bias. Through empirical evaluation, we show that FairLRM significantly enhances both fairness and recommendation accuracy, providing a more semantically aware and trustworthy approach to enhance the semantic understanding of popularity bias. The implementation is available at https://github.com/LuoRenqiang/FairLRM.