Simon See
Publications
NVAITC AI Scientist: A Governed End-to-End Research System -- A Hypertension GWAS Case Study
Agentic research systems are emerging as a new paradigm for coordinating scientific workflows beyond isolated model inference, code generation, or statistical analysis. However, deployment in institutional biomedical environments requires governed mechanisms for research planning, data access, workflow orchestration, evidence tracking, reproducibility, and human oversight. We present NVAITC AI Scientist (NAIS), a governed end-to-end agentic research system designed to support domain-general scientific workflows while keeping protected data within institutional privacy boundaries. NAIS integrates proposal review, execution planning, governed computational routing, reproducible workflow orchestration, evidence generation, and scientist-in-the-loop oversight. We validate NAIS in a real-world hypertension genome-wide association study (GWAS) using hospital-linked genotype and electronic health record (EHR) data from 286,422 individuals under an aggregate-only data policy. The agent planned cohort extraction, orchestrated GWAS execution, generated quality-control summaries, and drafted publication-oriented outputs. Human-AI review identified phenotype discrepancies and enabled iterative refinement of the hypertension definition. After reconciliation, the agent-orchestrated GWAS reproduced established hypertension loci, including FGF5, ATP2B1, CNNM2, FTO, and GRB14, with the strongest signal at FGF5 reaching $-\log_{10}(p) \sim 70$. As a secondary demonstration, NAIS also supported a drug-induced liver injury prediction workflow, achieving a multimodal graph neural network AUC of 0.842. These results demonstrate that governed agentic research systems can support scalable AI-assisted biomedical discovery while producing outputs comparable to expert-led workflows.
DAST: A Dual-Stream Voice Anonymization Attacker with Staged Training
Voice anonymization masks vocal traits while preserving linguistic content, which may still leak speaker-specific patterns. To assess and strengthen privacy evaluation, we propose a dual-stream attacker that fuses spectral and self-supervised learning features via parallel encoders with a three-stage training strategy. Stage I establishes foundational speaker-discriminative representations. Stage II leverages the shared identity-transformation characteristics of voice conversion and anonymization, exposing the model to diverse converted speech to build cross-system robustness. Stage III provides lightweight adaptation to target anonymized data. Results on the VoicePrivacy Attacker Challenge (VPAC) dataset demonstrate that Stage II is the primary driver of generalization, enabling strong attacking performance on unseen anonymization datasets. With Stage III, fine-tuning on only 10\% of the target anonymization dataset surpasses current state-of-the-art attackers in terms of EER.
A Vision-Language Foundation Model for Zero-shot Clinical Collaboration and Automated Concept Discovery in Dermatology
Medical foundation models have shown promise in controlled benchmarks, yet widespread deployment remains hindered by reliance on task-specific fine-tuning. Here, we introduce DermFM-Zero, a dermatology vision-language foundation model trained via masked latent modelling and contrastive learning on over 4 million multimodal data points. We evaluated DermFM-Zero across 20 benchmarks spanning zero-shot diagnosis and multimodal retrieval, achieving state-of-the-art performance without task-specific adaptation. We further evaluated its zero-shot capabilities in three multinational reader studies involving over 1,100 clinicians. In primary care settings, AI assistance enabled general practitioners to nearly double their differential diagnostic accuracy across 98 skin conditions. In specialist settings, the model significantly outperformed board-certified dermatologists in multimodal skin cancer assessment. In collaborative workflows, AI assistance enabled non-experts to surpass unassisted experts while improving management appropriateness. Finally, we show that DermFM-Zero's latent representations are interpretable: sparse autoencoders unsupervisedly disentangle clinically meaningful concepts that outperform predefined-vocabulary approaches and enable targeted suppression of artifact-induced biases, enhancing robustness without retraining. These findings demonstrate that a foundation model can provide effective, safe, and transparent zero-shot clinical decision support.
ReLA: Representation Learning and Aggregation for Job Scheduling with Reinforcement Learning
Job scheduling is widely used in real-world manufacturing systems to assign ordered job operations to machines under various constraints. Existing solutions remain limited by long running time or insufficient schedule quality, especially when problem scale increases. In this paper, we propose ReLA, a reinforcement-learning (RL) scheduler built on structured representation learning and aggregation. ReLA first learns diverse representations from scheduling entities, including job operations and machines, using two intra-entity learning modules with self-attention and convolution and one inter-entity learning module with cross-attention. These modules are applied in a multi-scale architecture, and their outputs are aggregated to support RL decision-making. Across experiments on small, medium, and large job instances, ReLA achieves the best makespan in most tested settings over the latest solutions. On non-large instances, ReLA reduces the optimality gap of the SOTA baseline by 13.0%, while on large-scale instances it reduces the gap by 78.6%, with the average optimality gaps lowered to 7.3% and 2.1%, respectively. These results confirm that ReLA's learned representations and aggregation provide strong decision support for RL scheduling, and enable fast job completion and decision-making for real-world applications.