2606.06379v1 Jun 04, 2026 cs.CV

EasyLens: A Training-Free Plug-and-Play Subtle-Lesion Representation Amplifier for Medical Vision-Language Models

Jinghao Lin
Jinghao Lin
Citations: 456
h-index: 4
Shuchang Ye
Shuchang Ye
Citations: 33
h-index: 3
Hao Wang
Hao Wang
Citations: 1
h-index: 1
Yige Peng
Yige Peng
Citations: 152
h-index: 7
Haoyuan Che
Haoyuan Che
Citations: 18
h-index: 2
Lei Bi
Lei Bi
Citations: 3,123
h-index: 30
Qiwei Zeng
Qiwei Zeng
Citations: 1
h-index: 1
Yuezhe Yang
Yuezhe Yang
Anhui University
Citations: 21
h-index: 2
Jinman Kim
Jinman Kim
Citations: 9
h-index: 2

Medical vision-language models (VLMs) have shown increasing potential for clinical image interpretation, including lesion detection and report generation. However, their practical utility remains limited by insufficient sensitivity to subtle lesions, whose visual evidence is often sparse, low-contrast, and embedded within complex anatomical context. As local visual tokens are aggregated, these weak lesion cues can become underrepresented in global image representations, making them difficult for medical VLMs to recognize. Existing efforts to improve lesion sensitivity mainly rely on medical-domain vision-encoder pre-training, clinical-term-guided alignment, or trainable pathological representation enhancement. Although effective, these approaches usually require additional training or model-specific adaptation and may overfit to particular disease morphologies, limiting their applicability to frozen medical VLMs. To address these limitations, we propose EasyLens, a training-free plug-and-play subtle-lesion representation amplifier for medical VLMs. EasyLens first constructs EasyBank, a pathology-anatomy prototype space that provides lesion-related prototypes and anatomy-aware normal references for comparing suspicious patches against both pathological and normal anatomical patterns. To avoid blindly amplifying normal tissues, EasyTag selects lesion-relevant patches through counterfactual prototype reasoning. To counteract the dilution of subtle lesion cues in global image representations, EasyAmplifier strengthens the selected lesion-relevant patch representations through morphology-guided residual enhancement, thereby increasing their contribution to the global image embedding. Experiments on multiple medical image datasets and frozen medical VLM backbones show that EasyLens improves subtle-lesion detection and outperforms existing encoder-enhancement baselines.

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