Yu Song
Publications
Improving scDiffusion with Sparsity-Biased Classifier-Free Guidance
Single-cell RNA sequencing (scRNA-seq) has become an essential tool in modern cellular biology, and generating accurate synthetic scRNA-seq data is becoming increasingly important. Although diffusion models have achieved promising results in conditional scRNA-seq generation, existing guidance strategies, including classifier guidance and classifier-free guidance (CFG), rely on an unconditional branch trained to approximate the true marginal distribution, which may retain substantial gene-specific structure and limit guidance effectiveness. Inspired by recent work showing that diffusion models can be effectively guided using intentionally degraded references, we propose a sparsity-biased classifier-free guidance (SB-CFG) strategy for scRNA-seq generation. Rather than approximating the assumed "neutral" marginal distribution, SB-CFG introduces a deliberately under-informative sparse reference for the unconditional branch, removing gene identity while preserving only coarse sparsity statistics. This "bad" reference amplifies the contrast between conditional and unconditional predictions, leading to stronger and more effective guidance during sampling. We evaluated SB-CFG as a training-free sampling modification on five publicly available scRNA-seq datasets. Experimental results demonstrate consistent improvements over standard CFG-based sampling in terms of marker gene expression fidelity, cell-type consistency, and sparsity preservation, indicating that SB-CFG better captures biologically meaningful gene expression patterns.
SAM+D: Parameter-Efficient Dimensional Lifting of SAM-Family Models via Depth-Routed LoRA and Depth Shifting
Existing methods for adapting 2D foundation models such as SAM to 3D volumes either process slices independently---ignoring inter-slice context---or require substantial architectural changes and retraining. In this paper, we present \textbf{SAM+D}, a parameter-efficient framework that lifts SAM-family models by one spatial dimension---enabling 3D volumetric segmentation from 2D SAM and, for the first time via parameter-efficient fine-tuning, end-to-end 4D (3D+T) spatiotemporal segmentation from video-based SAM2---while keeping the vast majority of pre-trained parameters frozen. SAM+D introduces two lightweight, model-agnostic modules into frozen transformer blocks: (1)~\textbf{Depth-Routed LoRA (DRLoRA)} experts with learned routing for spatially adaptive low-rank updates, and (2)~\textbf{Depth Shift Modules (DSM)} for cross-slice feature exchange at zero additional parameter cost. Together, they provide volume-level context while tuning only ${\sim}$2.8\% of parameters for SAM and ${\sim}$3.7\% for SAM2. We evaluate SAM+D in two distinct settings, each lifting the base model by one spatial dimension: 3D segmentation, where SAM(2D$\,\to\,$3D) is evaluated on four CT benchmarks (KiTS, Pancreas, LiTS, Colon), and 4D segmentation, where SAM2 (2D+T$\,\to\,$3D+T) is evaluated on a cell tracking challenge (CTC) dataset (Fluo-N3DH-SIM+). In both settings SAM+D achieves competitive or superior results under the single-point prompt setting while using fewer trainable parameters than existing methods, demonstrating that SAM+D generalizes across SAM-family architectures, target dimensionalities (3D, 4D), and domains spanning medical imaging and bio-scene understanding. Code is publicly available at https://github.com/JerrySongCST/SAM-Plus-D.
DynaBridge: Dynamic Summary-Guided Cross-Task Multimodal Fusion for DASS-Structured Mental Health Assessment
Multimodal behavioral analysis offers a scalable approach to assessing depression, anxiety, and stress, yet generic fusion models often ignore the psychometric structure of questionnaire labels. In DASS-21, risk labels are derived from ordered symptom items through fixed item-to-subscale mappings. We propose \textbf{DynaBridge}, a dynamic summary-guided cross-task multimodal framework for DASS-structured mental health assessment. DynaBridge encodes acoustic, visual, and textual cues across multiple sessions and augments them with frozen-LLM-generated DASS-aware summaries as participant-level semantic evidence. It predicts ordinal item distributions, reconstructs depression, anxiety, and stress risk evidence from item-level soft scores, and fuses this evidence with direct multimodal risk predictions. A confidence-aware refinement strategy further incorporates high-confidence semantic cues conservatively. On the official AdoDAS validation split, DynaBridge outperforms the official baseline and representative multimodal methods, achieving 0.5012 mean F1 for D/A/S risk prediction and 0.3216 mean QWK for DASS-21 item prediction. These results show the value of bridging multimodal cues, semantic summaries, and DASS-21 psychometric structure.
MIRTH: Mutual-Information Reasoning with Temporal Hubs for Vision-Language-Action Agents
VLA models have emerged as a powerful paradigm for transferring semantic knowledge from web-scale data to physical robotic control. However, current single-frame architectures suffer from intrinsic limitations: temporal myopia that discards historical dynamics, reasoning gaps between high-level instructions and low-level motor commands, and inference inefficiency due to autoregressive scalar decoding. In this work, we propose MIRTH, a unified framework designed to address these challenges. MIRTH augments a pretrained VLA backbone with three key innovations: (1) dual-scale temporal memory hubs that compress long-term scene evolution and short-term motion trends into compact embeddings; (2) latent reasoning tokens optimized via a mutual-information objective carving out a semantic plan space to align multimodal context with action trajectories; and (3) a parallel action decoding scheme that replaces autoregressive generation with vector-wise prediction to maximize control throughput. Extensive evaluations on the LIBERO simulation benchmark and a real-world LeRobot platform demonstrate that MIRTH achieves state-of-the-art performance and exhibiting emergent error recovery capabilities. The codes and collected datasets are released at http://github.com/kiva12138/mirth.