Xiaozhong Liu
Famous AuthorPublications
"Excuse me, may I say something..." CoLabScience, A Proactive AI Assistant for Biomedical Discovery and LLM-Expert Collaborations
The integration of Large Language Models (LLMs) into scientific workflows presents exciting opportunities to accelerate biomedical discovery. However, the reactive nature of LLMs, which respond only when prompted, limits their effectiveness in collaborative settings that demand foresight and autonomous engagement. In this study, we introduce CoLabScience, a proactive LLM assistant designed to enhance biomedical collaboration between AI systems and human experts through timely, context-aware interventions. At the core of our method is PULI (Positive-Unlabeled Learning-to-Intervene), a novel framework trained with a reinforcement learning objective to determine when and how to intervene in streaming scientific discussions, by leveraging the team's project proposal and long- and short-term conversational memory. To support this work, we introduce BSDD (Biomedical Streaming Dialogue Dataset), a new benchmark of simulated research discussion dialogues with intervention points derived from PubMed articles. Experimental results show that PULI significantly outperforms existing baselines in both intervention precision and collaborative task utility, highlighting the potential of proactive LLMs as intelligent scientific assistants.
Can We Trust a Black-box LLM? LLM Untrustworthy Boundary Detection via Bias-Diffusion and Multi-Agent Reinforcement Learning
Large Language Models (LLMs) have shown a high capability in answering questions on a diverse range of topics. However, these models sometimes produce biased, ideologized or incorrect responses, limiting their applications if there is no clear understanding of which topics their answers can be trusted. In this research, we introduce a novel algorithm, named as GMRL-BD, designed to identify the untrustworthy boundaries (in terms of topics) of a given LLM, with black-box access to the LLM and under specific query constraints. Based on a general Knowledge Graph (KG) derived from Wikipedia, our algorithm incorporates with multiple reinforcement learning agents to efficiently identify topics (some nodes in KG) where the LLM is likely to generate biased answers. Our experiments demonstrated the efficiency of our algorithm, which can detect the untrustworthy boundary with just limited queries to the LLM. Additionally, we have released a new dataset containing popular LLMs including Llama2, Vicuna, Falcon, Qwen2, Gemma2 and Yi-1.5, along with labels indicating the topics on which each LLM is likely to be biased.
VitalDiagnosis: AI-Driven Ecosystem for 24/7 Vital Monitoring and Chronic Disease Management
Chronic diseases have become the leading cause of death worldwide, a challenge intensified by strained medical resources and an aging population. Individually, patients often struggle to interpret early signs of deterioration or maintain adherence to care plans. In this paper, we introduce VitalDiagnosis, an LLM-driven ecosystem designed to shift chronic disease management from passive monitoring to proactive, interactive engagement. By integrating continuous data from wearable devices with the reasoning capabilities of LLMs, the system addresses both acute health anomalies and routine adherence. It analyzes triggers through context-aware inquiries, produces provisional insights within a collaborative patient-clinician workflow, and offers personalized guidance. This approach aims to promote a more proactive and cooperative care paradigm, with the potential to enhance patient self-management and reduce avoidable clinical workload.
Human-in-the-Loop Interactive Report Generation for Chronic Disease Adherence
Chronic disease management requires regular adherence feedback to prevent avoidable hospitalizations, yet clinicians lack time to produce personalized patient communications. Manual authoring preserves clinical accuracy but does not scale; AI generation scales but can undermine trust in patient-facing contexts. We present a clinician-in-the-loop interface that constrains AI to data organization and preserves physician oversight through recognition-based review. A single-page editor pairs AI-generated section drafts with time-aligned visualizations, enabling inline editing with visual evidence for each claim. This division of labor (AI organizes, clinician decides) targets both efficiency and accountability. In a pilot with three physicians reviewing 24 cases, AI successfully generated clinically personalized drafts matching physicians' manual authoring practice (overall mean 4.86/10 vs. 5.0/10 baseline), requiring minimal physician editing (mean 8.3\% content modification) with zero safety-critical issues, demonstrating effective automation of content generation. However, review time remained comparable to manual practice, revealing an accountability paradox: in high-stakes clinical contexts, professional responsibility requires complete verification regardless of AI accuracy. We contribute three interaction patterns for clinical AI collaboration: bounded generation with recognition-based review via chart-text pairing, automated urgency flagging that analyzes vital trends and adherence patterns with fail-safe escalation for missed critical monitoring tasks, and progressive disclosure controls that reduce cognitive load while maintaining oversight. These patterns indicate that clinical AI efficiency requires not only accurate models, but also mechanisms for selective verification that preserve accountability.