Chenrun Wang
Publications
Evidence-Grounded AI for Musculoskeletal Care
Musculoskeletal diseases are among the leading causes of disability worldwide and create the greatest global need for rehabilitation. Because recovery, remodelling and degeneration often unfold over months to years, musculoskeletal care requires longitudinal management that repeatedly integrates evolving patient evidence, external medical knowledge and stage-specific functional goals. In routine practice, this evidence is fragmented across visits, departments and hospital systems, limiting individualized, evidence-based care. Here we report OrthoPilot, a clinical artificial intelligence system powered by a large language model that integrates hospital data streams with authoritative external knowledge for continuous musculoskeletal management. OrthoPilot autonomously retrieves real-time imaging, laboratory, pathology and order data and converts evolving patient states into evidence-based decisions from admission diagnosis to rehabilitation planning. We established a specialist-validated benchmark from real-world electronic health records spanning 1,000 disease codes. In a reader study across the complete care pathway, OrthoPilot was compared with 81 orthopaedic physicians and surpassed experts with 25 years of experience in diagnostic reasoning, clinical decision-making and management planning. It also outperformed all evaluated intelligent systems across 60 external clinical centres. In a prospective study of 1,870 complex cases, OrthoPilot increased full-chain management success by 10.6%. During an 8-month randomised deployment involving 8,240 inpatients, it increased cumulative cases per bed by 9.7% and improved patient-reported access to health information. These results move clinical AI from predicting isolated events toward executing longitudinal management across complete musculoskeletal care pathways.
ManimAgent: Self-Evolving Multimodal Agents for Visual Education
Multi-round reflection lets agents built on large language models recover from failures within a single task, but each task remains an isolated episode: lessons learned across many reflection rounds on one task are discarded before the next begins. We study this gap on a code-generation task: from a scientific paper section, the agent writes Python in the open-source Manim library to render a mathematical animation. We present ManimAgent, a self-evolving multimodal agent that carries reflection experience across tasks through a dual-channel Episodic Memory Bank grown entirely from its own task stream, with no weight updates and no human seeds. After each animation converges, a vision-language model scores the rendered keyframes; the resulting signals populate a positive channel M+ that stores success rationales as soft Reference Examples, and a negative channel M- that stores validated failure patterns as hard Known Pitfalls. On a fixed-probe evaluation against no-memory, matched-budget retrieval-augmented generation, and shuffled-memory baselines, blind human Pass@1 rises and reflection rounds fall as memory size grows. We will release the code, frozen memory snapshots, and the task stream.
Externalizing Research Synthesis and Validation in AI Scientists through a Research Harness
AI systems can increasingly automate scientific workflows, but the reasoning that links prior evidence, generated ideas, experiments and final claims often remains implicit inside model inference. Here we introduce Xcientist, a research harness that externalizes research synthesis and experimental validation into inspectable, contract-governed processes. Xcientist organizes literature evidence, idea states, implementation plans, ablation records and repair traces as persistent research artifacts, so that generated mechanisms can be grounded, executed, tested and revised without losing their evidential basis. We identify claim drift as a failure mode of automated research, where runnable artifacts no longer support the mechanism originally claimed. Across training-free memory systems, graph-structured traffic forecasting and multi-scale physics-informed neural networks, Xcientist preserves traceable trajectories from problem formulation to mechanism design, validation and bounded revision. These results suggest that AI scientists should be evaluated not only by their final artifacts, but by whether their synthesis and validation processes remain attributable, inspectable and scientifically accountable.
DeepSurvey: Enhancing Analytical Depth and Citation Reliability in Automated Survey Generation
As scientific literature grows rapidly, automated survey generation has become a key capability for AI scientists and human researchers. However, existing systems suffer from limited analytical depth due to reliance on abstracts and isolated paper processing, and unreliable citations from imprecise retrieval and post-hoc grounding, producing superficial surveys and may mislead researchers. We present DeepSurvey, an agentic system that addresses both. To enhance depth, DeepSurvey extracts structured keynotes from full-text papers, models cross-paper relationships through clustering and comparative analysis, and integrates code-repository analysis to recover implementation-level details. To fortify reliability, it combines citation-graph expansion with hybrid filtering for topic-focussed retrieval, enforces evidence-constrained citation assignment, and deploys multi-granularity agentic refinement to validate citation-claim alignment. Experiments show that DeepSurvey achieves the highest content score (8.644/10) and citation quality (12.3% and 9.3% recall and precision gains over the strongest baseline), generalizes more robustly across domains (0.14 vs 0.22 to 0.69 CS-to-non-CS drop), and is preferred over human-written surveys by domain experts (83.3% overall quality, 100% content depth).