Quan Lu
Publications
ProtoAct: Turning Wet-Lab Protocols into Embodied Robotic Actions
Biological wet-lab protocols are written for trained researchers and often leave routine operations, state-dependent conditions, and contextual parameters implicit, making them difficult to translate into robot-executable actions. We present ProtoAct, a structured protocol-grounding framework that converts free-form biological procedures into state-aware, embodiment-ready action sequences. ProtoAct uses ProtoRAG to retrieve manually annotated examples for context-sensitive parsing, employs RefineChecker to detect and revise missing or inconsistent steps, and applies ActSchema to map the refined procedure into constrained JSON function sequences. We further introduce BioP2E, for which we manually annotate 22 cell-culture protocols into 258 monitoring conditions, 910 executable subtasks, and 962 grounded action calls. Evaluation across seven large language models demonstrates that ProtoAct can be effectively instantiated with different backbones. Ablations confirm that retrieval, posterior checking, and schema constraints make complementary contributions. The parsed subtasks further support demonstration collection and VLA model training, enabling successful execution in both simulation and real-robot settings. ProtoAct thus provides a practical interface between biological protocol understanding and embodied robotic execution.
BioVLN: A Simulation Platform for Visual Language Navigation in Biomedical Laboratories
Biomedical laboratory robots must navigate to instruments before performing experimental procedures. Existing embodied navigation platforms are designed for household environments and treat a target as an object center or an arbitrary nearby position. This representation is inadequate for laboratory instruments, which must be approached from their operating side while maintaining safe clearance from surrounding equipment. We introduce BioVLN, a simulation platform for developing and evaluating visual-language navigation agents in biomedical laboratories. BioVLN represents each instrument with three regions: its physical body, a surrounding clearance region, and an operation area in front of the usable side. This model is applied consistently to scene generation, target placement, navigation evaluation, and safety analysis, so success depends on reaching a position from which the instrument can be accessed. BioVLN supports procedural scene generation and manually designed environments, producing 47 scenes and 1667 episodes. Standardized navigation and reinforcement-learning interfaces enable trajectory collection and policy training. Experiments show that geometric exploration reaches 74.4--87.5% success, while sampling multiple valid positions in the operation area improves success to 83.3--92.5% and reduces unsafe proximity.
BioProVLA-Agent: An Affordable, Protocol-Driven, Vision-Enhanced VLA-Enabled Embodied Multi-Agent System with Closed-Loop-Capable Reasoning for Biological Laboratory Manipulation
Biological laboratory automation can reduce repetitive manual work and improve reproducibility, but reliable embodied execution in wet-lab environments remains challenging. Protocols are often unstructured, labware is frequently transparent or reflective, and multi-step procedures require state-aware execution beyond one-shot instruction following. Existing robotic systems often rely on costly hardware, fixed workflows, dedicated instruments, or robotics-oriented interfaces. Here, we introduce BioProVLA-Agent, an affordable, protocol-driven, vision-enhanced embodied multi-agent system enabled by Vision-Language-Action (VLA) models for biological manipulation. The system uses protocols as the task interface and integrates protocol parsing, visual state verification, and embodied execution in a closed-loop workflow. A Tailored LLM Protocol Agent converts protocols into verifiable subtasks; a VLM-RAG Verification Agent assesses readiness and completion using observations, robot states, retrieved knowledge, and success/failure examples; and a VLA Embodied Agent executes verified subtasks through a lightweight policy. To improve robustness under wet-lab visual perturbations, we develop AugSmolVLA, an online augmentation strategy targeting transparent labware, reflections, illumination shifts, and overexposure. We evaluate the system on a hierarchical benchmark covering 15 atomic tasks, 6 composite workflows, and 3 bimanual tasks, including tube loading, sorting, waste disposal, cap twisting, and liquid pouring. Across normal and high-exposure settings, AugSmolVLA improves execution stability over ACT, X-VLA, and the original SmolVLA, especially for precise placement, transparent-object manipulation, composite workflows, and visually degraded scenes. These results suggest a practical route toward accessible, protocol-centered, and verification-capable embodied AI for biological manipulation.