Wei Ruan
Publications
ASTELD: A Six-Axis Classification Framework for Autonomous AI Agents - Design, Evaluation, and an OpenClaw Case Study
Autonomous AI agent platforms differ substantially in architecture, security, tool integration, execution, autonomy, and deployment, yet the field lacks a common classification scheme for comparing these design choices. We propose ASTELD, an operational six-axis classification framework for autonomous AI agents: Architecture pattern, Security posture, Tool integration model, Execution paradigm, Level of autonomy and human control, and Deployment topology. ASTELD is constructed by synthesizing prior agent taxonomies with observable platform properties and explicit category-assignment rules. We evaluate its discriminative and explanatory utility by mapping eight representative frameworks and by using OpenClaw as an in-depth case study. The resulting profiles separate all eight platforms under their dominant configurations and reveal three cross-platform patterns: a security-accessibility diagonal, strong execution-architecture coupling, and capability convergence with persistent architectural differentiation. We further classify 50+ OpenClaw derivatives and find that innovation concentrates on the Security, Execution, and Deployment axes, indicating that ASTELD can explain where ecosystem fragmentation occurs. The OpenClaw case study also supplies a six-category vulnerability taxonomy, evidence from five institutional assessments, and adoption and governance analyses that connect platform coordinates to observed risks. These results position ASTELD as a reproducible method for comparing agent platforms, identifying unoccupied design regions, guiding framework selection, and organizing future empirical research. The analysis also exposes a consequential empty region: none of the evaluated systems combines local-first deployment with enterprise-grade security.
Vibe Medicine: Redefining Biomedical Research Through Human-AI Co-Work
With the emergence of large language models (LLMs) and AI agent frameworks, the human-AI co-work paradigm known as Vibe Coding is changing how people code, making it more accessible and productive. In scientific research, where workflows are more complex and the burden of specialized labor limits independent researchers and those in low-resource areas, the potential impact is even greater, particularly in biomedicine, which involves heterogeneous data modalities and multi-step analytical pipelines. In this paper, we introduce Vibe Medicine, a co-work paradigm in which clinicians and researchers direct skill-augmented AI agents through natural language to execute complex, multi-step biomedical workflows, while retaining the role of research director who specifies objectives, reviews intermediate results, and makes domain-informed decisions. The enabling infrastructure consists of three layers: capable LLMs, agent frameworks such as OpenClaw and Hermes Agent, and the OpenClaw medical skills collection, which includes more than 1,000 curated skills from multiple open-source repositories. We analyze the architecture and skill categories of this collection across ten biomedical domains, and present case studies covering rare disease diagnosis, drug repurposing, and clinical trial design that demonstrate end-to-end workflows in practice. We also identify the principal risks, such as hallucination, data privacy, and over-reliance, and outline directions toward more reliable, trustworthy, and clinically integrated agent-assisted research that advances research and technological equity and reduces health care resource disparities.