Linxuan Zhao
Publications
Vibe Medicine: Redefining Biomedical Research Through Human-AI Co-Work
With the emergence of large language models (LLMs) and AI agent frameworks, the human-AI co-work paradigm known as Vibe Coding is changing how people code, making it more accessible and productive. In scientific research, where workflows are more complex and the burden of specialized labor limits independent researchers and those in low-resource areas, the potential impact is even greater, particularly in biomedicine, which involves heterogeneous data modalities and multi-step analytical pipelines. In this paper, we introduce Vibe Medicine, a co-work paradigm in which clinicians and researchers direct skill-augmented AI agents through natural language to execute complex, multi-step biomedical workflows, while retaining the role of research director who specifies objectives, reviews intermediate results, and makes domain-informed decisions. The enabling infrastructure consists of three layers: capable LLMs, agent frameworks such as OpenClaw and Hermes Agent, and the OpenClaw medical skills collection, which includes more than 1,000 curated skills from multiple open-source repositories. We analyze the architecture and skill categories of this collection across ten biomedical domains, and present case studies covering rare disease diagnosis, drug repurposing, and clinical trial design that demonstrate end-to-end workflows in practice. We also identify the principal risks, such as hallucination, data privacy, and over-reliance, and outline directions toward more reliable, trustworthy, and clinically integrated agent-assisted research that advances research and technological equity and reduces health care resource disparities.
Scalable LLM-based Coding of Dialogue in Healthcare Simulation: Balancing Coding Performance, Processing Time, and Environmental Impact
Research shows that dialogue, the interactive process through which participants articulate their thinking, plays a central role in constructing shared understanding, coordinating action, and shaping learning outcomes in teams. Analysing dialogue content has been central to advancing team learning theory and informing the design of computer-supported collaborative learning environments, yet this progress has depended on labour-intensive qualitative coding. LLMs offer new possibilities for automating and enhancing the dialogue layer within emerging multimodal learning analytics approaches, with recent studies showing that they can approximate human coding through few-shot prompting. However, prior work has focused on replicating human coding accuracy for research purposes, rather than addressing a more educationally consequential question: how can we design prompts that allow an LLM to label team dialogue accurately and fast enough to be useful in real settings, such as in-person healthcare simulations, where results must be returned quickly and computational cost and sustainability also matter? This paper investigates how prompt design and batching strategies can be optimised to balance coding accuracy, processing time, and environmental impact in team-based healthcare simulation debriefing. Using a dataset of 11,647 utterances coded across 6 dialogue constructs, we compared 4 prompt designs across varying batch sizes, evaluating coding performance, processing time, and energy consumption, as well as the trade-offs between these metrics. Results indicate that increasing batch size improves speed and reduces energy use, but negatively impacts coding performance. Beyond demonstrating the feasibility of LLM-based qualitative analysis, this study offers practical guidance for scaling dialogue analytics in contexts where timeliness, privacy, and sustainability are critical.