Wei Zhou
Publications
When Does Persona Prompting Actually Help? A Retrieval and Metric Analysis of Expert Role Injection in LLMs
Persona prompting is widely used to steer large language models, yet its practical value remains unclear. Prior work often evaluates persona prompting using aggregate scores, making it difficult to determine whether expert-role prompting consistently improves response quality or instead changes responses along different quality dimensions. We study this question through a controlled comparison of four prompting conditions across 1,140 open-ended questions spanning 38 expert roles and six domains: no role prompt, a generic domain-expert prompt, embedding-based role retrieval, and a hybrid retrieval method combining embedding search with LLM-based role selection. Aggregate results show only small overall differences between conditions. However, metric-level analysis reveals a consistent tradeoff that aggregate averages obscure: role prompting systematically increases expertise depth while reducing clarity. These effects are highly conditional rather than universal. Role prompting performs best on advisory questions and in domains such as medicine and psychology, where structured expert framing and risk communication are intrinsically valuable. In contrast, baseline prompting performs better on conceptual and explanatory questions in finance, legal, science, and technology domains, where concise plain-language explanation is more important. We further show that hybrid retrieval significantly improves over embedding-only role selection, although better role retrieval does not eliminate the broader expertise-depth versus clarity tradeoff. Overall, our findings suggest that persona prompting primarily reshapes response characteristics rather than broadly improving capability, and that multi-metric evaluation is necessary for understanding its effects.
Schema-Adaptive Tabular Representation Learning with LLMs for Generalizable Multimodal Clinical Reasoning
Machine learning for tabular data remains constrained by poor schema generalization, a challenge rooted in the lack of semantic understanding of structured variables. This challenge is particularly acute in domains like clinical medicine, where electronic health record (EHR) schemas vary significantly. To solve this problem, we propose Schema-Adaptive Tabular Representation Learning, a novel method that leverages large language models (LLMs) to create transferable tabular embeddings. By transforming structured variables into semantic natural language statements and encoding them with a pretrained LLM, our approach enables zero-shot alignment across unseen schemas without manual feature engineering or retraining. We integrate our encoder into a multimodal framework for dementia diagnosis, combining tabular and MRI data. Experiments on NACC and ADNI datasets demonstrate state-of-the-art performance and successful zero-shot transfer to unseen schemas, significantly outperforming clinical baselines, including board-certified neurologists, in retrospective diagnostic tasks. These results validate our LLM-driven approach as a scalable, robust solution for heterogeneous real-world data, offering a pathway to extend LLM-based reasoning to structured domains.