Ming Y. Lu
Famous AuthorPublications
A multimodal and temporal foundation model for virtual patient representations at healthcare system scale
Modern medicine generates vast multimodal data across siloed systems, yet no existing model integrates the full breadth and temporal depth of the clinical record into a unified patient representation. We introduce Apollo, a multimodal temporal foundation model trained and evaluated on over three decades of longitudinal hospital records from a major US hospital system, composed of 25 billion records from 7.2 million patients, representing 28 distinct medical modalities and 12 major medical specialties. Apollo learns a unified representation space integrating over 100 thousand unique medical events in our clinical vocabulary as well as images and clinical text. This "atlas of medical concepts" forms a computational substrate for modeling entire patient care journeys comprised of sequences of structured and unstructured events, which are compressed by Apollo into virtual patient representations. To assess the potential of these whole-patient representations, we created 322 prognosis and retrieval tasks from a held-out test set of 1.4 million patients. We demonstrate the generalized clinical forecasting potential of Apollo embeddings, including predicting new disease onset risk up to five years in advance (95 tasks), disease progression (78 tasks), treatment response (59 tasks), risk of treatment-related adverse events (17 tasks), and hospital operations endpoints (12 tasks). Using feature attribution techniques, we show that model predictions align with clinically-interpretable multimodal biomarkers. We evaluate semantic similarity search on 61 retrieval tasks, and moreover demonstrate the potential of Apollo as a multimodal medical search engine using text and image queries. Together, these modeling capabilities establish the foundation for computable medicine, where the full context of patient care becomes accessible to computational reasoning.
From Query to Counsel: Structured Reasoning with a Multi-Agent Framework and Dataset for Legal Consultation
Legal consultation question answering (Legal CQA) presents unique challenges compared to traditional legal QA tasks, including the scarcity of high-quality training data, complex task composition, and strong contextual dependencies. To address these, we construct JurisCQAD, a large-scale dataset of over 43,000 real-world Chinese legal queries annotated with expert-validated positive and negative responses, and design a structured task decomposition that converts each query into a legal element graph integrating entities, events, intents, and legal issues. We further propose JurisMA, a modular multi-agent framework supporting dynamic routing, statutory grounding, and stylistic optimization. Combined with the element graph, the framework enables strong context-aware reasoning, effectively capturing dependencies across legal facts, norms, and procedural logic. Trained on JurisCQAD and evaluated on a refined LawBench, our system significantly outperforms both general-purpose and legal-domain LLMs across multiple lexical and semantic metrics, demonstrating the benefits of interpretable decomposition and modular collaboration in Legal CQA.