Lequan Yu
Publications
Evidence-Grounded AI for Musculoskeletal Care
Musculoskeletal diseases are among the leading causes of disability worldwide and create the greatest global need for rehabilitation. Because recovery, remodelling and degeneration often unfold over months to years, musculoskeletal care requires longitudinal management that repeatedly integrates evolving patient evidence, external medical knowledge and stage-specific functional goals. In routine practice, this evidence is fragmented across visits, departments and hospital systems, limiting individualized, evidence-based care. Here we report OrthoPilot, a clinical artificial intelligence system powered by a large language model that integrates hospital data streams with authoritative external knowledge for continuous musculoskeletal management. OrthoPilot autonomously retrieves real-time imaging, laboratory, pathology and order data and converts evolving patient states into evidence-based decisions from admission diagnosis to rehabilitation planning. We established a specialist-validated benchmark from real-world electronic health records spanning 1,000 disease codes. In a reader study across the complete care pathway, OrthoPilot was compared with 81 orthopaedic physicians and surpassed experts with 25 years of experience in diagnostic reasoning, clinical decision-making and management planning. It also outperformed all evaluated intelligent systems across 60 external clinical centres. In a prospective study of 1,870 complex cases, OrthoPilot increased full-chain management success by 10.6%. During an 8-month randomised deployment involving 8,240 inpatients, it increased cumulative cases per bed by 9.7% and improved patient-reported access to health information. These results move clinical AI from predicting isolated events toward executing longitudinal management across complete musculoskeletal care pathways.
CORA: Conformal Risk-Controlled Agents for Safeguarded Mobile GUI Automation
Graphical user interface (GUI) agents powered by vision language models (VLMs) are rapidly moving from passive assistance to autonomous operation. However, this unrestricted action space exposes users to severe and irreversible financial, privacy or social harm. Existing safeguards rely on prompt engineering, brittle heuristics and VLM-as-critic lack formal verification and user-tunable guarantees. We propose CORA (COnformal Risk-controlled GUI Agent), a post-policy, pre-action safeguarding framework that provides statistical guarantees on harmful executed actions. CORA reformulates safety as selective action execution: we train a Guardian model to estimate action-conditional risk for each proposed step. Rather than thresholding raw scores, we leverage Conformal Risk Control to calibrate an execute/abstain boundary that satisfies a user-specified risk budget and route rejected actions to a trainable Diagnostician model, which performs multimodal reasoning over rejected actions to recommend interventions (e.g., confirm, reflect, or abort) to minimize user burden. A Goal-Lock mechanism anchors assessment to a clarified, frozen user intent to resist visual injection attacks. To rigorously evaluate this paradigm, we introduce Phone-Harm, a new benchmark of mobile safety violations with step-level harm labels under real-world settings. Experiments on Phone-Harm and public benchmarks against diverse baselines validate that CORA improves the safety--helpfulness--interruption Pareto frontier, offering a practical, statistically grounded safety paradigm for autonomous GUI execution. Code and benchmark are available at cora-agent.github.io.