Philip Chikontwe
Publications
FDIR: Harmonizing Fidelity and Human-Machine Preference in Lossy Compression Image Restoration
Image restoration quality can be evaluated along three complementary facets: pixel-level fidelity, human perception, and downstream machine preference. However, existing lossy compression restoration methods optimize for at most one of these criteria: fidelity-oriented models often regress toward conditional means and produce over-smoothed outputs, while generative approaches hallucinate plausible but factually incorrect textures that degrade both ground-truth fidelity and downstream task accuracy. To navigate this three-way tradeoff, we propose FDIR, a two-stage architecture that decouples the conflicting demands through complementary inductive biases: Quality-Guided One-Step Flow Matching (QO-Flow) recovers global semantic structure in latent space via a single forward pass, while Flow-Conditioned Detail Refinement (FCDR) deterministically restores high-frequency textures and suppresses generative hallucinations in pixel space. Extensive experiments demonstrate that FDIR achieves superior fidelity, with a favorable perceptual-fidelity balance and competitive machine preference.
Computational Pathology in the Era of Emerging Foundation and Agentic AI -- International Expert Perspectives on Clinical Integration and Translational Readiness
Recent breakthroughs in artificial intelligence through foundation models and agents have accelerated the evolution of computational pathology. Demonstrated performance gains reported across academia in benchmarking datasets in predictive tasks such as diagnosis, prognosis, and treatment response have ignited substantial enthusiasm for clinical application. Despite this development momentum, real world adoption has lagged, as implementation faces economic, technical, and administrative challenges. Beyond existing discussions of technical architectures and comparative performance, this review considers how these emerging AI systems can be responsibly integrated into medical practice by connecting deployable clinical relevance with downstream analytical capabilities and their technical maturity, operational readiness, and economic and regulatory context. Drawing on perspectives from an international group, we provide a practical assessment of current capabilities and barriers to adoption in patient care settings.