Trong-Thang Pham
Publications
PolypSteer: Counterfactual Endoscopic Synthesis via Training-Free Activation Steering
Generative diffusion models are increasingly used for medical imaging data augmentation, but text prompting cannot produce causal training data. Re-prompting rerolls the entire generation trajectory, altering anatomy, texture, and background. Inversion-based editing methods introduce reconstruction error that causes structural drift. We propose PolypSteer, a training-free activation-steering framework for endoscopic synthesis. PolypSteer identifies a pathology vector for each contrastive prompt pair in the cross-attention layers of a diffusion transformer. At inference time, it steers image activations along this vector, generating counterfactual pairs from scratch where the only difference is the steered concept. All other structure is preserved by construction. We evaluate PolypSteer across three experiments on Kvasir v3 and HyperKvasir. On counterfactual generation across three clinical concept pairs, PolypSteer achieves flip rates of 0.800, 0.925, and 0.950, outperforming the best inversion-based baseline in both concept flip rate and structural preservation. On dye disentanglement, PolypSteer achieves 75% dye removal against 20% (PnP) and 10% (h-Edit). On downstream polyp detection, augmenting with PolypSteer counterfactual pairs achieves ViT AUC of 0.9755 versus 0.9083 for quantity-matched re-prompting, confirming that counterfactual structure drives the gain. Code is at link https://github.com/UARK-AICV/PolypSteer
DuFal: Dual-Frequency-Aware Learning for High-Fidelity Extremely Sparse-view CBCT Reconstruction
Sparse-view Cone-Beam Computed Tomography reconstruction from limited X-ray projections remains a challenging problem in medical imaging due to the inherent undersampling of fine-grained anatomical details, which correspond to high-frequency components. Conventional CNN-based methods often struggle to recover these fine structures, as they are typically biased toward learning low-frequency information. To address this challenge, this paper presents DuFal (Dual-Frequency-Aware Learning), a novel framework that integrates frequency-domain and spatial-domain processing via a dual-path architecture. The core innovation lies in our High-Local Factorized Fourier Neural Operator, which comprises two complementary branches: a Global High-Frequency Enhanced Fourier Neural Operator that captures global frequency patterns and a Local High-Frequency Enhanced Fourier Neural Operator that processes spatially partitioned patches to preserve spatial locality that might be lost in global frequency analysis. To improve efficiency, we design a Spectral-Channel Factorization scheme that reduces the Fourier Neural Operator parameter count. We also design a Cross-Attention Frequency Fusion module to integrate spatial and frequency features effectively. The fused features are then decoded through a Feature Decoder to produce projection representations, which are subsequently processed through an Intensity Field Decoding pipeline to reconstruct a final Computed Tomography volume. Experimental results on the LUNA16 and ToothFairy datasets demonstrate that DuFal significantly outperforms existing state-of-the-art methods in preserving high-frequency anatomical features, particularly under extremely sparse-view settings.