Yi Yang
Publications
ClinFusion: A Vision-Centric Multimodal LLM System for Holistic Medical Understanding
Multimodal large language models (MLLMs) hold immense potential to revolutionize clinical practice, yet deploying them in the medical domain is fundamentally a vision-centric challenge: models must absorb knowledge from heterogeneous 2D and 3D medical images, and evaluation protocols must align with radiologists' clinical practice and provide an accurate, fine-grained and factualness-driven assessment. In this paper, we introduce ClinFusion, a vision-centric MLLM designed for holistic medical understanding that systematically addresses these limitations. We propose a compositional and cascaded vision encoder architecture featuring a Cascade Spatial-Aware Locality Fusion operator that unifies diverse 2D and native 3D medical image understanding within a fused encoder. We further introduce a vision-grounded evaluation framework, including MedIF-Bench for instruction-following assessment and a region-of-interest-grounded method for clinically aligned and factualness-driven report generation evaluation. We show that ClinFusion sets a new state-of-the-art across a comprehensive suite of 2D and 3D multimodal medical benchmarks---spanning visual question answering, report generation, and instruction following---as well as textual medical tasks, outperforming leading open-source medical MLLMs (\textit{e.g.}, Hulu-Med, Lingshu) on 20 out of 24 benchmarks and demonstrating multimodal capabilities better than powerful proprietary models such as GPT-5.2 and Gemini-3-Flash on 13 out of 16 benchmarks, and can be further augmented with agentic tool use for retrieval-augmented and tool-assisted clinical workflows. A blinded evaluation by board-certified radiologists confirms that ClinFusion produces the highest-ranked reports, and validates our RoI-grounded metric as achieving the strongest correlation with expert judgment among all automatic evaluation metrics examined.
Chart-FR1: Visual Focus-Driven Fine-Grained Reasoning on Dense Charts
Multimodal large language models (MLLMs) have shown considerable potential in chart understanding and reasoning tasks. However, they still struggle with high information density (HID) charts characterized by multiple subplots, legends, and dense annotations due to three major challenges: (1) limited fine-grained perception results in the omission of critical visual cues; (2) redundant or noisy visual information undermines the performance of multimodal reasoning; (3) lack of adaptive deep reasoning relative to the amount of visual information. To tackle these challenges, we present a novel focus-driven fine-grained chart reasoning model, Chart-FR1, to improve perception, focusing efficiency, and adaptive deep reasoning on HID charts. Specifically, we propose Focus-CoT, a visual focusing chain-of-thought that enhances fine-grained perception by explicitly linking reasoning steps to key visual cues, such as local image regions and OCR signals. Building on this, we introduce Focus-GRPO, a focus-driven reinforcement learning algorithm with an information-efficiency reward that compresses redundant visual information for efficient focusing, and an adaptive KL penalty mechanism that enables flexible control over reasoning depth as more visual cues are discovered. Furthermore, to fill the gap in benchmarks for HID charts, we build HID-Chart, a challenging benchmark with an information-density metric designed to evaluate fine-grained chart reasoning capabilities. Extensive experiments on multiple chart benchmarks demonstrate that Chart-FR1 outperforms state-of-the-art MLLMs in chart understanding and reasoning. Code is available at https://github.com/phkhub/Chart-FR1.
V-Zero: Self-Improving Multimodal Reasoning with Zero Annotation
Recent advances in multimodal learning have significantly enhanced the reasoning capabilities of vision-language models (VLMs). However, state-of-the-art approaches rely heavily on large-scale human-annotated datasets, which are costly and time-consuming to acquire. To overcome this limitation, we introduce V-Zero, a general post-training framework that facilitates self-improvement using exclusively unlabeled images. V-Zero establishes a co-evolutionary loop by instantiating two distinct roles: a Questioner and a Solver. The Questioner learns to synthesize high-quality, challenging questions by leveraging a dual-track reasoning reward that contrasts intuitive guesses with reasoned results. The Solver is optimized using pseudo-labels derived from majority voting over its own sampled responses. Both roles are trained iteratively via Group Relative Policy Optimization (GRPO), driving a cycle of mutual enhancement. Remarkably, without a single human annotation, V-Zero achieves consistent performance gains on Qwen2.5-VL-7B-Instruct, improving visual mathematical reasoning by +1.7 and general vision-centric by +2.6, demonstrating the potential of self-improvement in multimodal systems. Code is available at https://github.com/SatonoDia/V-Zero