Jinhong Yu
Publications
"Excuse me, may I say something..." CoLabScience, A Proactive AI Assistant for Biomedical Discovery and LLM-Expert Collaborations
The integration of Large Language Models (LLMs) into scientific workflows presents exciting opportunities to accelerate biomedical discovery. However, the reactive nature of LLMs, which respond only when prompted, limits their effectiveness in collaborative settings that demand foresight and autonomous engagement. In this study, we introduce CoLabScience, a proactive LLM assistant designed to enhance biomedical collaboration between AI systems and human experts through timely, context-aware interventions. At the core of our method is PULI (Positive-Unlabeled Learning-to-Intervene), a novel framework trained with a reinforcement learning objective to determine when and how to intervene in streaming scientific discussions, by leveraging the team's project proposal and long- and short-term conversational memory. To support this work, we introduce BSDD (Biomedical Streaming Dialogue Dataset), a new benchmark of simulated research discussion dialogues with intervention points derived from PubMed articles. Experimental results show that PULI significantly outperforms existing baselines in both intervention precision and collaborative task utility, highlighting the potential of proactive LLMs as intelligent scientific assistants.
Human-in-the-Loop Interactive Report Generation for Chronic Disease Adherence
Chronic disease management requires regular adherence feedback to prevent avoidable hospitalizations, yet clinicians lack time to produce personalized patient communications. Manual authoring preserves clinical accuracy but does not scale; AI generation scales but can undermine trust in patient-facing contexts. We present a clinician-in-the-loop interface that constrains AI to data organization and preserves physician oversight through recognition-based review. A single-page editor pairs AI-generated section drafts with time-aligned visualizations, enabling inline editing with visual evidence for each claim. This division of labor (AI organizes, clinician decides) targets both efficiency and accountability. In a pilot with three physicians reviewing 24 cases, AI successfully generated clinically personalized drafts matching physicians' manual authoring practice (overall mean 4.86/10 vs. 5.0/10 baseline), requiring minimal physician editing (mean 8.3\% content modification) with zero safety-critical issues, demonstrating effective automation of content generation. However, review time remained comparable to manual practice, revealing an accountability paradox: in high-stakes clinical contexts, professional responsibility requires complete verification regardless of AI accuracy. We contribute three interaction patterns for clinical AI collaboration: bounded generation with recognition-based review via chart-text pairing, automated urgency flagging that analyzes vital trends and adherence patterns with fail-safe escalation for missed critical monitoring tasks, and progressive disclosure controls that reduce cognitive load while maintaining oversight. These patterns indicate that clinical AI efficiency requires not only accurate models, but also mechanisms for selective verification that preserve accountability.