Mingzhe Lu
Publications
DALPHIN: Benchmarking Digital Pathology AI Copilots Against Pathologists on an Open Multicentric Dataset
Foundation models with visual question answering capabilities for digital pathology are emerging. Such unprecedented technology requires independent benchmarking to assess its potential in assisting pathologists in routine diagnostics. We created DALPHIN, the first multicentric open benchmark for pathology AI copilots, comprising 1236 images from 300 cases, spanning 130 rare to common diagnoses, 6 countries, and 14 subspecialties. The DALPHIN design and dataset are introduced alongside a human performance benchmark of 31 pathologists from 10 countries with varying expertise. We report results for two general-purpose (GPT-5, Gemini 2.5 Pro) and one pathology-specific copilot (PathChat+) for sequential and independent answer generation. We observed no statistically significant difference from expert-level performance in four of six tasks for PathChat, 2/6 tasks for Gemini, and 1/6 tasks for GPT. DALPHIN is publicly released with sequestered, indirectly accessible ground truth to foster robust and enduring benchmarking. Data, methods, and the evaluation platform are accessible through dalphin.grand-challenge.org.
S^2tory: Story Spine Distillation for Movie Script Summarization
Movie scripts pose a fundamental challenge for automatic summarization due to their non-linear, cross-cut narrative structure, which makes surface-level saliency methods ineffective at preserving core story progression. To address this, we introduce S^2tory (Story Spine Distillation), a narratology-grounded framework that leverages character development trajectories to identify plot nuclei, the essential events that drive the narrative forward, while filtering out peripheral satellite events that merely enrich atmosphere or emotion. Our Narrative Expert Agent (NEAgent) performs theory-constrained reasoning, whose distilled knowledge conditions a small model to identify plot nuclei. Another model then uses these plot nuclei to generate the summary. Experiments on the MovieSum dataset demonstrate state-of-the-art semantic fidelity at approximately 3.5x compression, and zero-shot evaluation on BookSum confirms strong out-of-domain generalization. Human evaluation further validates that narratological theory provides an indispensable foundation for modeling complex, non-linear narratives.
LitVISTA: A Benchmark for Narrative Orchestration in Literary Text
Computational narrative analysis aims to capture rhythm, tension, and emotional dynamics in literary texts. Existing large language models can generate long stories but overly focus on causal coherence, neglecting the complex story arcs and orchestration inherent in human narratives. This creates a structural misalignment between model- and human-generated narratives. We propose VISTA Space, a high-dimensional representational framework for narrative orchestration that unifies human and model narrative perspectives. We further introduce LitVISTA, a structurally annotated benchmark grounded in literary texts, enabling systematic evaluation of models' narrative orchestration capabilities. We conduct oracle evaluations on a diverse selection of frontier LLMs, including GPT, Claude, Grok, and Gemini. Results reveal systematic deficiencies: existing models fail to construct a unified global narrative view, struggling to jointly capture narrative function and structure. Furthermore, even advanced thinking modes yield only limited gains for such literary narrative understanding.