Muchen Li
Publications
Point transformer for protein structural heterogeneity analysis using CryoEM
Structural dynamics of macromolecules is critical to their structural-function relationship. Cryogenic electron microscopy (CryoEM) provides snapshots of vitrified protein at different compositional and conformational states, and the structural heterogeneity of proteins can be characterized through computational analysis of the images. For protein systems with multiple degrees of freedom, it is still challenging to disentangle and interpret the different modes of dynamics. Here, by implementing Point Transformer, a self-attention network designed for point cloud analysis, we are able to improve the performance of heterogeneity analysis on CryoEM data, and characterize the dynamics of highly complex protein systems in a more human-interpretable way.
MOSS Transcribe Diarize Technical Report
Speaker-Attributed, Time-Stamped Transcription (SATS) aims to transcribe what is said and to precisely determine the timing of each speaker, which is particularly valuable for meeting transcription. Existing SATS systems rarely adopt an end-to-end formulation and are further constrained by limited context windows, weak long-range speaker memory, and the inability to output timestamps. To address these limitations, we present MOSS Transcribe Diarize, a unified multimodal large language model that jointly performs Speaker-Attributed, Time-Stamped Transcription in an end-to-end paradigm. Trained on extensive real wild data and equipped with a 128k context window for up to 90-minute inputs, MOSS Transcribe Diarize scales well and generalizes robustly. Across comprehensive evaluations, it outperforms state-of-the-art commercial systems on multiple public and in-house benchmarks.