Qiangqiang Dai
Publications
OpenRTAG: A Comprehensive Benchmark for Robust Text-Attributed Graph Learning under Data Quality Degradation
Text-attributed graphs (TAGs) are an important graph data form that combine relational structure with rich node text. However, real-world TAGs are often imperfect, with quality issues arising from text, structure, and labels, and typically manifesting as sparsity, noise, and imbalance. These dimensions define nine representative degradation scenarios that can substantially affect TAG learning. Although prior studies have explored specific mitigation strategies, existing evidence remains fragmented across degradation types, datasets, tasks, and model families, leaving TAG robustness insufficiently understood. To address this gap, we present OpenRTAG, a robustness benchmark for text-attributed graph learning. OpenRTAG organizes TAG quality issues into a unified 3 * 3 taxonomy and supports standardized evaluation across nine TAG datasets and three downstream tasks. It systematically evaluates scenario validity and model sensitivity, compares traditional GNNs, LLM-GNNs, and a representative GFM, investigates the effectiveness, efficiency, and robustness of scenario-matched baselines, and further examines model behavior under composite degradation scenarios. OpenRTAG provides a standardized testbed for understanding robustness in TAG learning under realistic low-quality settings.
DOGMA: Weaving Structural Information into Data-centric Single-cell Transcriptomics Analysis
Recently, data-centric AI methodology has been a dominant paradigm in single-cell transcriptomics analysis, which treats data representation rather than model complexity as the fundamental bottleneck. In the review of current studies, earlier sequence methods treat cells as independent entities and adapt prevalent ML models to analyze their directly inherited sequence data. Despite their simplicity and intuition, these methods overlook the latent intercellular relationships driven by the functional mechanisms of biological systems and the inherent quality issues of the raw sequence data. Therefore, a series of structured methods has emerged. Although they employ various heuristic rules to capture intricate intercellular relationships and enhance the raw sequencing data, these methods often neglect biological prior knowledge. This omission incurs substantial overhead and yields suboptimal graph representations, thereby hindering the utility of ML models. To address them, we propose DOGMA, a holistic data-centric framework designed for the structural reshaping and semantic enhancement of raw data through multi-level biological prior knowledge. Transcending reliance on stochastic heuristics, DOGMA redefines graph construction by integrating Statistical Anchors with Cell Ontology and Phylogenetic Trees to enable deterministic structure discovery and robust cross-species alignment. Furthermore, Gene Ontology is utilized to bridge the feature-level semantic gap by incorporating functional priors. In complex multi-species and multi-organ benchmarks, DOGMA achieves SOTA performance, exhibiting superior zero-shot robustness and sample efficiency while operating with significantly lower computational cost.