Wenxuan Huang
Publications
AblateCell: A Reproduce-then-Ablate Agent for Virtual Cell Repositories
Systematic ablations are essential to attribute performance gains in AI Virtual Cells, yet they are rarely performed because biological repositories are under-standardized and tightly coupled to domain-specific data and formats. While recent coding agents can translate ideas into implementations, they typically stop at producing code and lack a verifier that can reproduce strong baselines and rigorously test which components truly matter. We introduce AblateCell, a reproduce-then-ablate agent for virtual cell repositories that closes this verification gap. AblateCell first reproduces reported baselines end-to-end by auto-configuring environments, resolving dependency and data issues, and rerunning official evaluations while emitting verifiable artifacts. It then conducts closed-loop ablation by generating a graph of isolated repository mutations and adaptively selecting experiments under a reward that trades off performance impact and execution cost. Evaluated on three single-cell perturbation prediction repositories (CPA, GEARS, BioLORD), AblateCell achieves 88.9% (+29.9% to human expert) end-to-end workflow success and 93.3% (+53.3% to heuristic) accuracy in recovering ground-truth critical components. These results enable scalable, repository-grounded verification and attribution directly on biological codebases.
SkillFlow:Benchmarking Lifelong Skill Discovery and Evolution for Autonomous Agents
As the capability frontier of autonomous agents continues to expand, they are increasingly able to complete specialized tasks through plug-and-play external skills. Yet current benchmarks mostly test whether models can use provided skills, leaving open whether they can discover skills from experience, repair them after failure, and maintain a coherent library over time. We introduce SkillFlow, a benchmark of 166 tasks across 20 families in which task construction within each family follows a Domain-Agnostic Execution Flow (DAEF) that defines an agent workflow framework, allowing these tasks to share a consistent workflow. Agents are evaluated under an Agentic Lifelong Learning protocol in which they begin without skills, solve tasks sequentially within each family, externalize lessons through trajectory- and rubric-driven skill patches, and carry the updated library forward. Experiments reveal a substantial capability gap. For Claude Opus 4.6, lifelong skill evolution improves task success from 62.65% to 71.08% (+8.43 points). However, high skill usage does not necessarily imply high utility: Kimi K2.5 gains only +0.60 points despite 66.87% skill usage, while Qwen-Coder-Next reaches only a 44.58% task completion rate and still regresses relative to the vanilla setting. SkillFlow contributes a structured testbed for this direction and an in-depth empirical analysis of skill discovery, patching, transfer, and their failure modes under lifelong evaluation.
Vision-DeepResearch Benchmark: Rethinking Visual and Textual Search for Multimodal Large Language Models
Multimodal Large Language Models (MLLMs) have advanced VQA and now support Vision-DeepResearch systems that use search engines for complex visual-textual fact-finding. However, evaluating these visual and textual search abilities is still difficult, and existing benchmarks have two major limitations. First, existing benchmarks are not visual search-centric: answers that should require visual search are often leaked through cross-textual cues in the text questions or can be inferred from the prior world knowledge in current MLLMs. Second, overly idealized evaluation scenario: On the image-search side, the required information can often be obtained via near-exact matching against the full image, while the text-search side is overly direct and insufficiently challenging. To address these issues, we construct the Vision-DeepResearch benchmark (VDR-Bench) comprising 2,000 VQA instances. All questions are created via a careful, multi-stage curation pipeline and rigorous expert review, designed to assess the behavior of Vision-DeepResearch systems under realistic real-world conditions. Moreover, to address the insufficient visual retrieval capabilities of current MLLMs, we propose a simple multi-round cropped-search workflow. This strategy is shown to effectively improve model performance in realistic visual retrieval scenarios. Overall, our results provide practical guidance for the design of future multimodal deep-research systems. The code will be released in https://github.com/Osilly/Vision-DeepResearch.
Vision-DeepResearch: Incentivizing DeepResearch Capability in Multimodal Large Language Models
Multimodal large language models (MLLMs) have achieved remarkable success across a broad range of vision tasks. However, constrained by the capacity of their internal world knowledge, prior work has proposed augmenting MLLMs by ``reasoning-then-tool-call'' for visual and textual search engines to obtain substantial gains on tasks requiring extensive factual information. However, these approaches typically define multimodal search in a naive setting, assuming that a single full-level or entity-level image query and few text query suffices to retrieve the key evidence needed to answer the question, which is unrealistic in real-world scenarios with substantial visual noise. Moreover, they are often limited in the reasoning depth and search breadth, making it difficult to solve complex questions that require aggregating evidence from diverse visual and textual sources. Building on this, we propose Vision-DeepResearch, which proposes one new multimodal deep-research paradigm, i.e., performs multi-turn, multi-entity and multi-scale visual and textual search to robustly hit real-world search engines under heavy noise. Our Vision-DeepResearch supports dozens of reasoning steps and hundreds of engine interactions, while internalizing deep-research capabilities into the MLLM via cold-start supervision and RL training, resulting in a strong end-to-end multimodal deep-research MLLM. It substantially outperforming existing multimodal deep-research MLLMs, and workflows built on strong closed-source foundation model such as GPT-5, Gemini-2.5-pro and Claude-4-Sonnet. The code will be released in https://github.com/Osilly/Vision-DeepResearch.
UniCorn: Towards Self-Improving Unified Multimodal Models through Self-Generated Supervision
While Unified Multimodal Models (UMMs) have achieved remarkable success in cross-modal comprehension, a significant gap persists in their ability to leverage such internal knowledge for high-quality generation. We formalize this discrepancy as Conduction Aphasia, a phenomenon where models accurately interpret multimodal inputs but struggle to translate that understanding into faithful and controllable synthesis. To address this, we propose UniCorn, a simple yet elegant self-improvement framework that eliminates the need for external data or teacher supervision. By partitioning a single UMM into three collaborative roles: Proposer, Solver, and Judge, UniCorn generates high-quality interactions via self-play and employs cognitive pattern reconstruction to distill latent understanding into explicit generative signals. To validate the restoration of multimodal coherence, we introduce UniCycle, a cycle-consistency benchmark based on a Text to Image to Text reconstruction loop. Extensive experiments demonstrate that UniCorn achieves comprehensive and substantial improvements over the base model across six general image generation benchmarks. Notably, it achieves SOTA performance on TIIF(73.8), DPG(86.8), CompBench(88.5), and UniCycle while further delivering substantial gains of +5.0 on WISE and +6.5 on OneIG. These results highlight that our method significantly enhances T2I generation while maintaining robust comprehension, demonstrating the scalability of fully self-supervised refinement for unified multimodal intelligence.