Mingxuan Wang
Publications
ScDiVa: Masked Discrete Diffusion for Joint Modeling of Single-Cell Identity and Expression
Single-cell RNA-seq profiles are high-dimensional, sparse, and unordered, causing autoregressive generation to impose an artificial ordering bias and suffer from error accumulation. To address this, we propose scDiVa, a masked discrete diffusion foundation model that aligns generation with the dropout-like corruption process by defining a continuous-time forward masking mechanism in token space. ScDiVa features a bidirectional denoiser that jointly models discrete gene identities and continuous values, utilizing entropy-normalized serialization and a latent anchor token to maximize information efficiency and preserve global cell identity. The model is trained via depth-invariant time sampling and a dual denoising objective to simulate varying sparsity levels while ensuring precise recovery of both identity and magnitude. Pre-trained on 59 million cells, scDiVa achieves strong transfer performance across major benchmarks, including batch integration, cell type annotation, and perturbation response prediction. These results suggest that masked discrete diffusion serves as a biologically coherent and effective alternative to autoregression.
MathDoc: Benchmarking Structured Extraction and Active Refusal on Noisy Mathematics Exam Papers
The automated extraction of structured questions from paper-based mathematics exams is fundamental to intelligent education, yet remains challenging in real-world settings due to severe visual noise. Existing benchmarks mainly focus on clean documents or generic layout analysis, overlooking both the structural integrity of mathematical problems and the ability of models to actively reject incomplete inputs. We introduce MathDoc, the first benchmark for document-level information extraction from authentic high school mathematics exam papers. MathDoc contains \textbf{3,609} carefully curated questions with real-world artifacts and explicitly includes unrecognizable samples to evaluate active refusal behavior. We propose a multi-dimensional evaluation framework covering stem accuracy, visual similarity, and refusal capability. Experiments on SOTA MLLMs, including Qwen3-VL and Gemini-2.5-Pro, show that although end-to-end models achieve strong extraction performance, they consistently fail to refuse illegible inputs, instead producing confident but invalid outputs. These results highlight a critical gap in current MLLMs and establish MathDoc as a benchmark for assessing model reliability under degraded document conditions. Our project repository is available at \href{https://github.com/winnk123/papers/tree/master}{GitHub repository}