Chen Jiang
Publications
Disco: Densely-overlapping Cell Instance Segmentation via Adjacency-aware Collaborative Coloring
Accurate cell instance segmentation is foundational for digital pathology analysis. Existing methods based on contour detection and distance mapping still face significant challenges in processing complex and dense cellular regions. Graph coloring-based methods provide a new paradigm for this task, yet the effectiveness of this paradigm in real-world scenarios with dense overlaps and complex topologies has not been verified. Addressing this issue, we release a large-scale dataset GBC-FS 2025, which contains highly complex and dense sub-cellular nuclear arrangements. We conduct the first systematic analysis of the chromatic properties of cell adjacency graphs across four diverse datasets and reveal an important discovery: most real-world cell graphs are non-bipartite, with a high prevalence of odd-length cycles (predominantly triangles). This makes simple 2-coloring theory insufficient for handling complex tissues, while higher-chromaticity models would cause representational redundancy and optimization difficulties. Building on this observation of complex real-world contexts, we propose Disco (Densely-overlapping Cell Instance Segmentation via Adjacency-aware COllaborative Coloring), an adjacency-aware framework based on the "divide and conquer" principle. It uniquely combines a data-driven topological labeling strategy with a constrained deep learning system to resolve complex adjacency conflicts. First, "Explicit Marking" strategy transforms the topological challenge into a learnable classification task by recursively decomposing the cell graph and isolating a "conflict set." Second, "Implicit Disambiguation" mechanism resolves ambiguities in conflict regions by enforcing feature dissimilarity between different instances, enabling the model to learn separable feature representations.
PRPO: Aligning Process Reward with Outcome Reward in Policy Optimization
Policy optimization for large language models often suffers from sparse reward signals in multi-step reasoning tasks. Critic-free methods like GRPO assign a single normalized outcome reward to all tokens, providing limited guidance for intermediate reasoning . While Process Reward Models (PRMs) offer dense feedback, they risk premature collapse when used alone, as early low-reward tokens can drive policies toward truncated outputs. We introduce Process Relative Policy Optimization (PRPO), which combines outcome reliability with process-level guidance in a critic-free framework. PRPO segments reasoning sequences based on semantic clues, normalizes PRM scores into token-level advantages, and aligns their distribution with outcome advantages through location-parameter shift. On MATH500, PRPO improves Qwen2.5-Math-1.5B accuracy from 61.2% to 64.4% over GRPO using only eight rollouts and no value network, demonstrating efficient fine-grained credit assignment within critic-free optimization. Code is available at: https://github.com/SchumiDing/srpocode