Alan L. Yuille
Publications
Meissa: Multi-modal Medical Agentic Intelligence
Multi-modal large language models (MM-LLMs) have shown strong performance in medical image understanding and clinical reasoning. Recent medical agent systems extend them with tool use and multi-agent collaboration, enabling complex decision-making. However, these systems rely almost entirely on frontier models (e.g., GPT), whose API-based deployment incurs high cost, high latency, and privacy risks that conflict with on-premise clinical requirements. We present Meissa, a lightweight 4B-parameter medical MM-LLM that brings agentic capability offline. Instead of imitating static answers, Meissa learns both when to engage external interaction (strategy selection) and how to execute multi-step interaction (strategy execution) by distilling structured trajectories from frontier models. Specifically, we propose: (1) Unified trajectory modeling: trajectories (reasoning and action traces) are represented within a single state-action-observation formalism, allowing one model to generalize across heterogeneous medical environments. (2) Three-tier stratified supervision: the model's own errors trigger progressive escalation from direct reasoning to tool-augmented and multi-agent interaction, explicitly learning difficulty-aware strategy selection. (3) Prospective-retrospective supervision: pairing exploratory forward traces with hindsight-rationalized execution traces enables stable learning of effective interaction policies. Trained on 40K curated trajectories, Meissa matches or exceeds proprietary frontier agents in 10 of 16 evaluation settings across 13 medical benchmarks spanning radiology, pathology, and clinical reasoning. Using over 25x fewer parameters than typical frontier models like Gemini-3, Meissa operates fully offline with 22x lower end-to-end latency compared to API-based deployment. Data, models, and environments are released at https://github.com/Schuture/Meissa.
Shared LoRA Subspaces for almost Strict Continual Learning
Adapting large pretrained models to new tasks efficiently and continually is crucial for real-world deployment but remains challenging due to catastrophic forgetting and the high cost of retraining. While parameter-efficient tuning methods like low rank adaptation (LoRA) reduce computational demands, they lack mechanisms for strict continual learning and knowledge integration, without relying on data replay, or multiple adapters. We propose Share, a novel approach to parameter efficient continual finetuning that learns and dynamically updates a single, shared low-rank subspace, enabling seamless adaptation across multiple tasks and modalities. Share constructs a foundational subspace that extracts core knowledge from past tasks and incrementally integrates new information by identifying essential subspace directions. Knowledge from each new task is incorporated into this evolving subspace, facilitating forward knowledge transfer, while minimizing catastrophic interference. This approach achieves up to 100x parameter reduction and 281x memory savings over traditional LoRA methods, maintaining performance comparable to jointly trained models. A single Share model can replace hundreds of task-specific LoRA adapters, supporting scalable, asynchronous continual learning. Experiments across image classification, natural language understanding, 3D pose estimation, and text-to-image generation validate its effectiveness, making Share a practical and scalable solution for lifelong learning in large-scale AI systems.