Hangjie Yuan
Publications
ClinFusion: A Vision-Centric Multimodal LLM System for Holistic Medical Understanding
Multimodal large language models (MLLMs) hold immense potential to revolutionize clinical practice, yet deploying them in the medical domain is fundamentally a vision-centric challenge: models must absorb knowledge from heterogeneous 2D and 3D medical images, and evaluation protocols must align with radiologists' clinical practice and provide an accurate, fine-grained and factualness-driven assessment. In this paper, we introduce ClinFusion, a vision-centric MLLM designed for holistic medical understanding that systematically addresses these limitations. We propose a compositional and cascaded vision encoder architecture featuring a Cascade Spatial-Aware Locality Fusion operator that unifies diverse 2D and native 3D medical image understanding within a fused encoder. We further introduce a vision-grounded evaluation framework, including MedIF-Bench for instruction-following assessment and a region-of-interest-grounded method for clinically aligned and factualness-driven report generation evaluation. We show that ClinFusion sets a new state-of-the-art across a comprehensive suite of 2D and 3D multimodal medical benchmarks---spanning visual question answering, report generation, and instruction following---as well as textual medical tasks, outperforming leading open-source medical MLLMs (\textit{e.g.}, Hulu-Med, Lingshu) on 20 out of 24 benchmarks and demonstrating multimodal capabilities better than powerful proprietary models such as GPT-5.2 and Gemini-3-Flash on 13 out of 16 benchmarks, and can be further augmented with agentic tool use for retrieval-augmented and tool-assisted clinical workflows. A blinded evaluation by board-certified radiologists confirms that ClinFusion produces the highest-ranked reports, and validates our RoI-grounded metric as achieving the strongest correlation with expert judgment among all automatic evaluation metrics examined.
MCIE: Multimodal LLM-Driven Complex Instruction Image Editing with Spatial Guidance
Recent advances in instruction-based image editing have shown remarkable progress. However, existing methods remain limited to relatively simple editing operations, hindering real-world applications that require complex and compositional instructions. In this work, we address these limitations from the perspectives of architectural design, data, and evaluation protocols. Specifically, we identify two key challenges in current models: insufficient instruction compliance and background inconsistency. To this end, we propose MCIE-E1, a Multimodal Large Language Model-Driven Complex Instruction Image Editing method that integrates two key modules: a spatial-aware cross-attention module and a background-consistent cross-attention module. The former enhances instruction-following capability by explicitly aligning semantic instructions with spatial regions through spatial guidance during the denoising process, while the latter preserves features in unedited regions to maintain background consistency. To enable effective training, we construct a dedicated data pipeline to mitigate the scarcity of complex instruction-based image editing datasets, combining fine-grained automatic filtering via a powerful MLLM with rigorous human validation. Finally, to comprehensively evaluate complex instruction-based image editing, we introduce CIE-Bench, a new benchmark with two new evaluation metrics. Experimental results on CIE-Bench demonstrate that MCIE-E1 consistently outperforms previous state-of-the-art methods in both quantitative and qualitative assessments, achieving a 23.96% improvement in instruction compliance.
A$^2$-LLM: An End-to-end Conversational Audio Avatar Large Language Model
Developing expressive and responsive conversational digital humans is a cornerstone of next-generation human-computer interaction. While large language models (LLMs) have significantly enhanced dialogue capabilities, most current systems still rely on cascaded architectures that connect independent modules. These pipelines are often plagued by accumulated errors, high latency, and poor real-time performance. Lacking access to the underlying conversational context, these pipelines inherently prioritize rigid lip-sync over emotional depth. To address these challenges, we propose A$^2$-LLM, an end-to-end conversational audio avatar large language model that jointly reasons about language, audio prosody, and 3D facial motion within a unified framework. To facilitate training, we introduce FLAME-QA, a high-quality multimodal dataset designed to align semantic intent with expressive facial dynamics within a QA format. By leveraging deep semantic understanding, A$^2$-LLM generates emotionally rich facial movements beyond simple lip-synchronization. Experimental results demonstrate that our system achieves superior emotional expressiveness while maintaining real-time efficiency (500 ms latency, 0.7 RTF).