Nikola Simidjievski
Publications
KnowsTFM: Knowledge-Informed Fine-Tuning of Small Tabular Foundation Models
Tabular foundation models have advanced deep learning for tabular data by delivering strong default performance across many small and medium tasks. Yet in niche domains, where data is scarce, high-dimensional, and shifted from the pretraining distribution, they may still fail to outperform carefully designed domain-specific methods. Many such domains also provide curated relational knowledge in the form of knowledge graphs and knowledge banks, but how to use this knowledge to improve and steer \textit{small} specialist tabular foundation models remains unclear. We address this problem through \textbf{Know}ledge-informed fine-tuning of \textbf{s}mall \textbf{T}abular \textbf{F}oundation \textbf{M}odels (\modelname). Specifically, we study nanoscale TabPFN- and TabICL-style variants, pretrained under controlled synthetic prior families and adapted using two complementary mechanisms: structural attention priors derived from knowledge graphs and parameter-efficient low-rank updates. We show that injecting domain-specific structural knowledge during fine-tuning yields meaningful gains over vanilla variants in specialist settings, whereas gains on general-domain tasks are marginal. We further observe that continual fine-tuning of frontier models can trigger collapse of pretrained knowledge and mechanisms.
Towards Spatial Transcriptomics-driven Pathology Foundation Models
Spatial transcriptomics (ST) provides spatially resolved measurements of gene expression, enabling characterization of the molecular landscape of human tissue beyond histological assessment as well as localized readouts that can be aligned with morphology. Concurrently, the success of multimodal foundation models that integrate vision with complementary modalities suggests that morphomolecular coupling between local expression and morphology can be systematically used to improve histological representations themselves. We introduce Spatial Expression-Aligned Learning (SEAL), a vision-omics self-supervised learning framework that infuses localized molecular information into pathology vision encoders. Rather than training new encoders from scratch, SEAL is designed as a parameter-efficient vision-omics finetuning method that can be flexibly applied to widely used pathology foundation models. We instantiate SEAL by training on over 700,000 paired gene expression spot-tissue region examples spanning tumor and normal samples from 14 organs. Tested across 38 slide-level and 15 patch-level downstream tasks, SEAL provides a drop-in replacement for pathology foundation models that consistently improves performance over widely used vision-only and ST prediction baselines on slide-level molecular status, pathway activity, and treatment response prediction, as well as patch-level gene expression prediction tasks. Additionally, SEAL encoders exhibit robust domain generalization on out-of-distribution evaluations and enable new cross-modal capabilities such as gene-to-image retrieval. Our work proposes a general framework for ST-guided finetuning of pathology foundation models, showing that augmenting existing models with localized molecular supervision is an effective and practical step for improving visual representations and expanding their cross-modal utility.