Zhigang Zeng
Publications
PathMem: Toward Cognition-Aligned Memory Transformation for Pathology MLLMs
Computational pathology demands both visual pattern recognition and dynamic integration of structured domain knowledge, including taxonomy, grading criteria, and clinical evidence. In practice, diagnostic reasoning requires linking morphological evidence with formal diagnostic and grading criteria. Although multimodal large language models (MLLMs) demonstrate strong vision language reasoning capabilities, they lack explicit mechanisms for structured knowledge integration and interpretable memory control. As a result, existing models struggle to consistently incorporate pathology-specific diagnostic standards during reasoning. Inspired by the hierarchical memory process of human pathologists, we propose PathMem, a memory-centric multimodal framework for pathology MLLMs. PathMem organizes structured pathology knowledge as a long-term memory (LTM) and introduces a Memory Transformer that models the dynamic transition from LTM to working memory (WM) through multimodal memory activation and context-aware knowledge grounding, enabling context-aware memory refinement for downstream reasoning. PathMem achieves SOTA performance across benchmarks, improving WSI-Bench report generation (12.8% WSI-Precision, 10.1% WSI-Relevance) and open-ended diagnosis by 9.7% and 8.9% over prior WSI-based models.
Diagnosing Knowledge Conflict in Multimodal Long-Chain Reasoning
Multimodal large language models (MLLMs) in long chain-of-thought reasoning often fail when different knowledge sources provide conflicting signals. We formalize these failures under a unified notion of knowledge conflict, distinguishing input-level objective conflict from process-level effective conflict. Through probing internal representations, we reveal that: (I) Linear Separability: different conflict types are explicitly encoded as linearly separable features rather than entangled; (II) Depth Localization: conflict signals concentrate in mid-to-late layers, indicating a distinct processing stage for conflict encoding; (III) Hierarchical Consistency: aggregating noisy token-level signals along trajectories robustly recovers input-level conflict types; and (IV) Directional Asymmetry: reinforcing the model's implicit source preference under conflict is far easier than enforcing the opposite source. Our findings provide a mechanism-level view of multimodal reasoning under knowledge conflict and enable principled diagnosis and control of long-CoT failures.